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In view of the rapid development of GSH-responsive and -exhausting metal nanomedicines in potentiating cancer therapy, we summarize and outline the recent advancements, mechanisms, prospects, and challenges in this field from different strategies (Scheme 1)
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Sequence Modified IGF-1 (N-terminal extension + Arg3 substitution) Molecular weight 9120 Da Mechanism ~3 free fraction vs native IGF-1
Dosage and Frequency: Once a week taken on the same day each week, any time of day, with or without food
Animal studies show significant improvements in body composition, metabolic markers, and muscle function with minimal adverse effects
Regulation 503A/503B pharmacy compounding under federal law Clinical Trials CJC-1295 reached Phase 2
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