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Endothelial function improves with weight loss, allowing better vasodilation in response to physiologic demand The expected magnitude of BP improvement with weight loss is approximately 1 mmHg systolic per kilogram lost in the early phase, with smaller gains as weight loss progresses

Compounds that appeared promising in preclinical and early clinical data have failed in later-phase trials repeatedly

Important safety information: These medications carry a boxed warning about the risk of thyroid C-cell tumors and are contraindicated in patients with a personal or family history of medullary thyroid carcinoma (MTC) or Multiple Endocrine Neoplasia syndrome type 2 (MEN2)

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Tissue collection Both BALF and whole blood were kept on ice and then centrifuged to separate the BAL cells and plasma, respectively