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IGF-1 LR3 and Stem Cell Culture Research IGF-1 LR3 binds to the IGF-1 receptor and is a potent activator of the PI3K/AKT pathway and ERK1/2 signalling, and has been shown to be required for human pluripotent stem cell maintenance in the absence of insulin, as well as stimulating differentiation and proliferation of myeloid cells alongside IL-3 and regulating lymphopoiesis by supporting T and B cell development in lymphoid organs

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By examining a variety of Bcr-Abl downstream signals including pAkt-S473, pS6K-T389 in the PI3K/Akt/mTOR pathway, and pStat5-Y694, we confirmed these signals similarly elevated in these two different transformed cells

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