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Pickart, L., et al
When the blood glucose level is high (a condition known as hyperglycemia), it can induce harmful changes in the brain, such as inflammation, oxidative stress, and damage to brain cells
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This differential efficiency of reprogramming was also reflected in the transcriptomes of these cells, as evaluated by the enrichment of a reprogramming score composed of genes previously reported in MEFs that are poised to reprogram at 72 h of OSKM expression 48 (Extended Data Fig
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