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Understanding how to activate L-cells naturally represents one of the most powerful strategies for optimizing metabolic health

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TRIUMPH-1 (80 Weeks) The pivotal TRIUMPH-1 obesity trial (2,339 adults, no diabetes), presented at ADA 2026, extended the treatment window to 80 weeks and produced the largest pivotal weight-loss readout to date: Among the 12 mg group, 45.3% lost at least 30% of their body weight and 65.3% ended the trial with a BMI below 30

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Insulin transport across the blood-brain barrier can occur independently of the insulin receptor

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