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GSH prevents LOsG-induced pancreatic fibrosis via the TGF/SMAD pathway in vivo Considering the crucial role of TGF-1 in organ fibrosis, we examined whether LOsG contributed to TGF-1 expression by detecting TGF-1 protein levels in pancreatic tissues using western blotting

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Ferroptosis: an important player in the inflammatory response in diabetic nephropathy

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With persistent hypoxia, HIF-1 remains activated and drives abnormal expression of downstream genes, including heme oxygenase-1 ( H O -1 ) (Zhai et al., 2023)