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Administration of CCK, in humans and animals, inhibits food intake by reducing meal size and its duration.17,18 Recent work suggests that CCK-A receptors expressed by vagal afferent neurons are an important target for CCK in producing sensations of satiety, as well as inhibiting gastric emptying and stimulating pancreatic digestive enzyme secretion.19 In animals it is thought that the reduction in food intake may be mediated by a paracrine/neurocrine effect since high concentrations of CCK occur only locally to the site of release.20 Thus, locally released CCK may increase vagal tone, without a significant increase in plasma CCK level

Current research often focuses on analyzing data from clinical trials and post-marketing surveillance reports to identify potential safety signals and trends related to hair loss following the use of these medications

Weight management remains fundamental (Waheed et al., 2021

I think that this has the potential to set many people down the paths of eating disorders if we arent careful.

[2] Hu XK, et al

It has been granted orphan drug designation by the FDA for the prevention of delayed graft function in kidney transplant patients and has completed a Phase 1 dose-ranging safety study in healthy volunteers