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a-c , Difference in abundance in the extracellular cysteinylglycine in medium (a) and relative abundance of intracellular cysteinylglycine (b) and intracellular cysteine (c) for HCC-1806 cells grown in the indicated conditions and time points (n = 3 technical replicates representative from 2 independent experiments, except for c at 24 h, in which n = 2 technical replicates from 2 independent experiments)

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The chromatogram, purity of spectra, the purity of peak, and all recorded spectra of the N-Hcy-Lys peak have been shown in Figs

This stability profile is one reason the fragment was selected for further mechanistic study after its identification in the parent gastric protein

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Through the cleavage of the C-terminal dipeptide, ACE alters the molecular structure of bradykinin in KKS, causing a loss of function that results in vasoconstriction and elevated blood pressure