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This makes it particularly relevant in clinical contexts where someone has gut lining compromise alongside systemic inflammation, for example, long-term NSAID use for chronic pain

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Frequently discussed areas include extracellular-matrix regulation, collagen-associated pathways, wound-model biology, oxidative-stress signaling, inflammatory signaling, angiogenesis-related models, and gene-expression profiling

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This sequence is thought to be a small fraction of the large protein collagen, which is one of the main proteins in the extracellular matrix of skin and other tissues