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[12] [23] In pivotal studies, setmelanotide produced clinically meaningful weight loss in selected patients with melanocortin pathway disorders

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Resmetirom acts on hepatocytes via the THR- receptor to reduce hepatic fat content, improve mitochondrial function and alleviate liver inflammation and fibrosis, whereas semaglutide acts systemically, outside the liver, to reduce energy intake, promote weight loss and improve insulin sensitivity [68, 69]

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For researchers managing metabolic health beyond the number on the scale, this benefit has no equivalent in tirzepatide protocols