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CAFs and extracellular matrix (ECM) paracrine HGF activate MET signaling A variety of stromal cells, known as CAFs, exhibit a wide range of origins, phenotypes, and functions [37, 38]

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Non-Metabolic Procedures Metabolic operations, such as sleeve gastrectomy, gastric bypass and duodenal switch, alter the gastrointestinal tract and change hormone levels like ghrelin, GLP-1 and PYY, which affect hunger and metabolism

Glucagon-like peptide-1 receptor (GLP-1R) agonists are effective anti-obesity drugs but their use is limited by side effects

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