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FDA-approved drugs: These are made by licensed pharmacies (503A or 503B) for specific patients with a valid prescription

Most patients who experience heartburn on GLP-1 therapy have identifiable contributing factors, such as large meal portions, eating close to bedtime, or underlying GERD that may have been previously undiagnosed or inadequately managed

This information will help your GP assess whether there may be a temporal relationship between starting the medication and the onset of symptoms, and whether a referral to a mental health service or a review of your treatment is appropriate

Unlike single agonist drugs like semaglutide or dual agonists like tirzepatide, Retatrutide activates three distinct hormone pathways that work together to promote weight loss through multiple complementary mechanisms

Can it affect hormones

Important safety considerations include potential reduced effectiveness of oral hormonal contraceptives during initiation and dose escalation (requiring non-oral or backup contraception for 4 weeks after each change) and that Zepbound is not recommended during pregnancy due to potential fetal risk