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Emerging evidence suggests direct metabolic and cellular effects on hepatocytes, adipose tissue, gut-liver signaling pathways, and systemic inflammatory networks

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Studies Linking GLP-1 Medications to NAION Several peer-reviewed studies have confirmed an increased risk of NAION in patients taking GLP-1 drugs: Harvard Medical School & Mass General Brigham Study (JAMA Ophthalmology, 2024) 9% of diabetic patients taking semaglutide developed NAION, compared to 1.8% on other diabetes drugs (a 4-fold increased risk)

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Endothelial nitric oxide synthase (eNOS) and the cardiovascular system: in physiology and in disease States