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In rodents, Botfield and colleagues [103] demonstrated that exendin-4 administration reduced intracranial pressure in hydrocephalic female rats

To date, the presence of GLP-1R in the renal vasculature has been confirmed but not in the tubules ( Oxidative Stress/Inflammation GLP-1RAs have been shown to prevent renal oxidative stress by inhibiting nicotinamide adenine dinucleotide phosphate (NADPH) oxidase through the activation of PKA and the production of cyclic adenosine monophosphate (cAMP)

For instance, L-carnitine, L-acetyl carnitine, NAC, and vitamin E have been reported to require a duration of 6-12 months (52, 56, 57, 62, 63)

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