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137, 807 (2006) , (8) J.B

The potential inhibitory effect of the compounds on transporter activity was further evaluated using the half-maximal inhibitory concentration (IC 50 )

25,3437 In patients who need to minimize weight gain or lose weight, addition of basal insulin is advised only after addition of other agents such as GLP-1 RAs, SGLT-2 inhibitors, or DPP-4 inhibitors

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Semaglutide is approved by the FDA for treatment of type 2 diabetes and for chronic weight management in adults with obesity or overweight

MR-Egger regression indicated no significant horizontal pleiotropy (Supplementary Table S6), supporting the validity of our primary findings