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A 2024 Phase 2 trial in Nature Medicine (Sanyal et al.) showed liver fat fell by 43% to 82% across the dose range in 24 weeks in patients with MASLD
TAKARA) was used to remove the genomic DNA and synthesize the cDNA
It removes water, rendering the molecule stable for transport and storage
Microdosing involves taking smaller, more frequent doses rather than the standard once-weekly injection
It is designed around the pharmacokinetics of reaching steady state at each dose before adding more
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