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Furthermore, liraglutide exerted anti-catabolic activity by significantly decreasing the activities of metalloproteinases and aggrecanases, a family of catabolic enzymes involved in cartilage breakdown in vitro

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Int J Obes (Lond) 40:13101319 Winslow DH, Bowden CH, DiDonato KP, McCullough PA (2012) A randomized, double-blind, placebo-controlled study of an oral, extended-release formulation of phentermine/topiramate for the treatment of obstructive sleep apnea in obese adults

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Interestingly, none of the semaglutide patents are listed on the Canadian Patent Register, meaning that enforcement through the linkage regime is unavailable