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And Kardashian isnt the only celebrity getting into the supplement craze: Last year, Halle Berry joined Pendulum Therapeutics, which sells a GLP-1 boosting probiotic, as an investor and chief communications officer

Separately, research in adults losing weight through caloric restriction has found that resistance training combined with adequate protein preserves most lean mass

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The TRIUMPH-4 Phase 3 trial in obesity with knee osteoarthritis later reported 28.7% mean weight loss at 68 weeks with retatrutide 12 mg/week, and identified a dose-related dysesthesia (nerve-tingling) signal in 8.8% of 9 mg and 20.9% of 12 mg patients (Bays et al., 2025)

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