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In vitro investigations revealed its capacity to downregulate inflammatory gene expression and suppress the synthesis of interleukin 6 (IL-6), prostaglandin E2 and nitric oxide in chondrocytes and macrophages in a dose-dependent manner

For any compound to work transdermally, it must be small enough to penetrate through multiple skin layers and achieve therapeutic concentrations in the bloodstream

Probiotics are a powerful tool in this process, but theyre most effective when combined with a healthy lifestyle

By comparison, the lower-dose, three-day-a-week regimen utilized in this study is markedly different

Therefore, more interventions and experimental studies are needed to address the existing knowledge gaps (74)