473 Mixed lineage kinase 3, a member of the MAP3K family, regulates the JNK/p53 pathway to mediate SLC7A11 expression and oxidative stress, causing myocardial fibrosis in the late stage of chronic heart failure in the TAC mouse model
126 The upregulation of IDH1 may represent a common metabolic adaptation for diminishing oxidative stress and supporting macromolecular synthesis, consequently promoting tumor growth and therapy resistance
Imaging modalities like ultrasound or elastography can help gauge changes in liver fat and stiffness, respectively
Acute paracetamol (acetaminophen) overdose is the clearest clinical demonstration of glutathione's hepatic importance: paracetamol toxicity depletes hepatic GSH, causing liver damage, and N-acetyl cysteine (NAC) a GSH precursor is the established antidote
Koroleva, S
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