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The landmark 2017 Cell study (Baar MP et al., PMID: 28340339) demonstrated that: (1) FOXO4 protein specifically accumulates in senescent cells where it binds to p53 and prevents p53 from triggering apoptosis (this is the specific mechanism being targeted)
This provides 4 weeks between injections in the same area
Many clinics offer numbing creams or ice to further minimize discomfort during the procedure
Am J Psychiatry 148:484488
10.1016/j.redox.2017.10.015 238
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