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The picture is one of systems-level pharmacology rather than single-target agonism
Most patients do not need additional numbing, or anesthetic
The nerve damage of vitamin B12 deficiency may be related to this
These patients are on a Pernicious Anaemia hospital ward where they were kept alive by eating just cooked or raw liver And imagine the further joy when a decade or so later they were provided with a monthly injection of grown B12
Two injections of the same drug at the same site don't qualify
Yadav R, Kataky J, Mathur R (1998) Phytoconstituents of Phlogacanthus tubiflorus Nees (Acanthaceae): Phlogacanthin, a new diterpene lactone (andrographolide) isolated from the root wood
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