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In 2016, 43.0% of the global adult population were current drinkers and caused 5.3% of all deaths ( Chronic heavy consumption of alcohol causes injuries in the organism, notably in the digestive, immune and central nervous system (CNS)

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Tolerance Tolerance refers to a gradual decreased response to a drug, requiring a higher dose of drug to achieve the same initial response

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The PET list mode data was reconstructed into 30 frames (12 10 s, 6 30 s, 5 120 s, 5 300 s, 2 600 s) using an iterative VPFX-S algorithm (three iterations, three subsets, matrix 256 256, Z-axis post-filter 3 mm) with all relevant corrections performed