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One real-world study found nearly half of the people who used an earlier generation of GLP-1 medication for diabetes quit within a year and 70% within two years.Meanwhile, about 4% of people in a clinical trial stopped taking Wegovy because of side effects

10.3389/fneur.2018.00292 55 DetsiA.BouloumbasiD.ProusisK

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This is the therapeutic sweet spot for many researchers, where the balance of efficacy and tolerability optimizes

1 For pharmacists on the frontlines of diabetes management, these findings provide a robust mechanistic rationale for the cardiovascular and multiorgan protection observed in large-scale clinical trials

Proceedings of the National Academy of Sciences, 106(6), 19421947.