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Severe caloric restriction depletes these reserves, whilst hormonal changes from rapid weight loss compound the effect by altering thyroid function and increasing cortisol levels, further disrupting normal follicular activity

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list price as of April 2026 (Novo Nordisk published pricing)

Split dosing aims to smooth the concentration curve at full therapeutic levels

Novo Nordisk is using this strategy to defend and extend its obesity leadership beyond semaglutide alone

Maintaining cold chain is essential for reliable treatment outcomes