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Side effects are rare and usually mild
Creatine is a rational companion supplement here
Mar 30 2020;10(4)doi:10.3390/ani10040581
It is likely that the larger number of statistically significant changes to the microbiome observed in the groups switched from WD to LD reflects their more numerous exposures to different diets, longitudinal changes in dietary exposure, the stress associated with diet switch, the negative energy state achieved by treatment and/or diet-driven weight loss, or a combination of these factors, but it may also be related to differences in terminal body weight and fat mass since both adiposity and diet composition have been shown to modulate the mouse gut microbiome profile
First, the components cannot be separated after reconstitution, so protocols needing an independently chosen ratio require separate vials
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