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7 Self-medication guided by GPs has numerous benefits such as reducing the primary care burden and improving patient empowerment

For instance, in mouse embryonic stem cells, targeted disruption of glucose-6-phosphate dehydrogenase, which is the rate-limiting enzyme in the pentose phosphate pathway, the predominant metabolic pathway for the generation of NADPH (a cofactor of GR), renders cells extremely sensitive to H 2 O 2 -induced cell death 34

Peirano RI et al

'Hugely expensive' Irene Roberts, professor of paediatric haematology, at the University of Oxford, said: "Reducing or stopping transfusions is important for patients with thalassaemia because they are a double-edged sword- essential for survival but also responsible for life-changing, life-shortening side-effects

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PharmaNutrition, 14 , 100209