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Rambhia and Dr

Studies on surgically resected specimens afford direct evidence of CYP induction (55, 147, 168), and also on-going oxidative stress : structural aberrations by microscopy (Table 1) (24), FRA signals (155), increased FROP with decreased GSH (5, 133), increased concentrations of pro-oxidant metals (copper, iron) but decreased levels of antioxidant metals (zinc, selenium) (5)

Mutations in C9orf72 result in aberrant RNA repeats that trap proteins such as TDP-43, causing RNA metabolism to be disrupted and toxic dipeptide repeat proteins (DPRs) to be produced

PMID: 3861195

But we see much less issues with growth hormone stimulating peptides

Small extracellular vesicles (sEVs) are particles of approximately 100 nm in size that are secreted from the cells