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Activation of these receptors may modulate dopamine signaling, potentially reducing alcohol's rewarding properties, though the exact mechanisms in humans remain under investigation

(2009) Medicinal Chemistry Approaches to the Inhibition of Dipeptidyl Peptidase-4 for the Treatment of Type 2 Diabetes

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Signal sensitivity pulsed dosing is the conservative way to avoid blunting the response over time

10.1016/j.cmet.2010.08.015 Cell Metab

All patients complete a medical evaluation and informed consent before beginning treatment