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Mechanistically, it has been observed that GSTP1-1 binds, in its monomeric form, both c-Jun and JNK, thus forming an heterotrimeric complex that inhibits the phosphorylation of c-Jun by JNK
In the second step, GSSG is reduced via the thiol-disulfide interchange reaction (Rao and Reddy 2008
doi: 10.1016/j.pcd.2024.03.005 53
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Miyamoto M, Murphy TH, Schnaar RL, Coyle JT
Prescription medication is available only after consultation and approval by a licensed healthcare provider, if clinically appropriate
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