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Link Christou, G
The findings demonstrated that Semaglutide produces clinically meaningful and sustained weight loss, and most importantly, provides cardiovascular benefits irrespective of the amount of weight lost, highlighting its broad impact on metabolic health
4.1 Clinical relevance of the CLP model The CLP model was selected for its unique ability to recapitulate core clinical features of SAE: polymicrobial sepsis, hippocampal neurodegeneration, and chronic cognitive impairment ( 4.2 Microglia-mediated oxidative neuronal injury Microglial activation initiates neuronal damage, and a previous study revealed that the microglial inhibitor minocycline reduces neuronal apoptosis ( in vivo oxidative stress ( Mechanistically, a microglial inflammation-oxidative stress feedforward loop perpetuates injury: Activated microglia secrete neurotoxins, impairing neuronal mitochondrial function and antioxidant capacity (such as GPX4), thus increasing ROS leakage
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The CCBL2 encoded protein was formerly known as kynurenine aminotransferase III (KAT III or KAT3)
