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They reported the use of GLP-1s was tied to a higher risk for DR (HR = 1.07
In the liver, cholesterol is converted into primary BAs, such as cholic acids (CAs) and chenodeoxycholic acids (CDCAs), which are subsequently conjugated with glycine or taurine [85]
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This finding has major practical implications
They exert anti-inflammatory effects by activating the nuclear receptor Farnesoid X receptor (FXR) and membrane receptor Takeda G-protein-coupled receptor 5 (TGR5), both of which are found in microglia and neurons
This mechanism creates satiety , but it also means that big portions can feel heavy for hours
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