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Hypoxia stress was modeled by placing rats into a flow pressure chamber for 15 minutes under 0.26 bar, which simulates an altitude of 10,000 m above ground level

So it sounds like the safety margin's probably pretty good for this

They come from vendor product pages and forum threads (LongeCity and similar), which is why this guide frames them as reported rather than recommended

Individuals with asthma or reactive airway disease should avoid inhaled forms

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The experimental animal, properly identified by its weight number, should be securely restrained by an assistant, positioning the animal with its head downward and abdomen upward