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Compared to the crystal structure or simulation of PF-06372222, these residues (marked red in e g ) were exposed to solvent by 40100 2 in the simulation of compound 2 ( g , i )
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GLP-1 has been proposed to have a role in lung protection (105), although this has primarily been described in rodents, where the GLP-1R is expressed at higher levels (87) and also in more diverse cell types (e.g., type 2 pneumocytes) than in humans (106)
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