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Semaglutide and tirzepatide are FDA-approved, orforglipron is under review, retatrutide remains in Phase 3 trials, and CagriSema has not been submitted

The ER is a central organelle for proinsulin folding, a capacity that is often overwhelmed in insulin-resistant states (Cunha et al., 2009)

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10.1172/JCI176660 39 ZhangC.XieY.ChenH.LvL.YaoJ.ZhangM.et al (2020)

Cholelithiasis (PT) was the most frequently reported AE across all drugs, with exenatide (n = 356, 70.36%) exhibiting the highest proportion, followed by liraglutide (n = 314, 63.95%), dulaglutide (n = 120, 63.49%), tirzepatide (n = 95, 59.75%), and semaglutide (n = 261, 55.18%)