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Figure 1 It is well known that the pharmacodynamic property of metformin is anti-diabetic, but there is growing evidence that it has a number of extra-hypoglycemic effects

Participants were aware of the treatment they were receiving

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At the same time, withholding GLP-1RAs in the perioperative period is not without risk, as it may lead to suboptimal glycaemic control and loss of the cardiometabolic benefits associated with continued therapy [28, 42]

Coverage and cost This is a huge deciding factor for most people

The complexity arises from the individual mechanisms of action of each substance