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While these dietary factors may influence GLP-1 secretion or activity, its essential to focus on overall dietary patterns and lifestyle habits

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The Phase 2b protocol used one dose per day for 12 weeks

A phase 2 trial of semaglutide 2.4 mg in 71 cirrhotic patients confirmed an acceptable safety profile without significant decompensation events, although the primary histological endpoint was not met, possibly due to the limited ability of antifibrotic remodeling to achieve biopsy-detectable fibrosis stage improvement in established cirrhosis over 48 weeks [46]