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Research in animal models shows activity at approximately 0.5mcg/kg, though human protocols typically use standardized doses in the 1-3mg range regardless of body weight

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However, severe persistent vomiting (more than 3 episodes per day for more than 2 days), signs of pancreatitis (severe abdominal pain radiating to the back), or allergic reactions (hives, difficulty breathing, facial swelling) warrant immediate protocol cessation and medical attention

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