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3,4 Referred to as the incretin effect , they exert their effects by binding to their respective receptors of the pancreas beta cells to ultimately release insulin

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Almost all efficacy data come from a single research group, and independent replication of the larger-effect-size studies remains limited

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Dose frequency and formulation : Many GLP-1 medications are injected once weekly

For example, in the SELECT trial (17,600 patients with cardiovascular disease and obesity but without T2D), weekly subcutaneous Semaglutide (2.4 mg) reduced the risk of major adverse cardiovascular events (MACE heart attack, stroke, or cardiovascular death) by 20% compared to placebo (HR 0.80