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Validation strategies, split-sample testing, permutation analyses, and receiver operating characteristic (ROC) curves, have confirmed the discriminatory capacity of small metabolite panels (46 compounds), with many models reaching area under the curve (AUC) values greater than 0.85

In parallel, defective autophagic clearance and ubiquitin-proteasome system dysfunction result in the accumulation of toxic protein species and damaged organelles, perpetuating cellular toxicity [5052]

Nijhoff WA et al

"N-acetylcysteine a safe antidote for cysteine/glutathione deficiency"

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