The slower emptying of the stomach means that alcohol absorption is affected too: less food intake leads to increased effects of alcohol, and even just one drink may feel different
Genetic evidence, such as GWAS, has identified the single-nucleotide polymorphism (SNP) in GIPR, showing that lower function of GIPR is associated with lower BMI (6466), allowing speculation that higher GIPR activity is obesity promoting
Specifically, treated granulosa cells exhibit reduced reactive oxygen species and enhanced mitochondrial membrane potential, both of which are associated with oocyte health
Sugerman HJ, et al
Since adipose tissue is responsive to endotoxins, bacterial translocation may provide a mechanism whereby the gut microbiome can modulate the adipose metabolome (for review, Kruis et al., 2014 23 ) and consequently exacerbate obesity and its related comorbidities
And that bone-deep fatigue that coffee can't touch