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doi: 10.1016/j.envpol.2020.115957 45 CholanP
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GLP-1 and Appetite Regulation: The Role of Brain-Gut Signaling GLP-1 is not only produced in the gut but also acts in the brains hypothalamus, where it influences hunger and satiety signals
In the body, GLP-1, together with glucose-dependent insulinotropic polypeptide (GIP), accounts for 90% of the incretin effect
This is where weight loss with semaglutide can help
GLP-1 receptor agonists work through several mechanisms: they enhance insulin secretion when blood glucose levels are elevated, suppress glucagon release (which reduces glucose production by the liver), slow gastric emptying, and promote satiety through effects on appetite centres in the brain
