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Nishida, T
Certain retained components of various cell death pathways such as Fas (CD95)/Fas ligand (FasL, CD95L) signaling, caspase-3, caspase-8, or RIPK1/RIPK3 (receptor-interacting serine/threonine-protein kinase 3)/MLKL (mixed lineage kinase domain like pseudokinase) axis can be considered a heritage of the erythroid lineage cells
It can make it harder to know which compound is helping, which one is causing side effects, and how the overall protocol should be adjusted
In a nutshell, which formulation we choose depends on where we inject, as well as your individual area of concern/s
Fujita Y, Watanabe K, Maki K
2016;39(suppl 1):S52-S59
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