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Sermorelin is the older, broader, less-validated GHRH peptide with FDA approval limited to pediatric GH deficiency

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The LR3 extension does not make it "safer" -- it makes it longer-acting and less regulated by binding proteins, which from a risk standpoint means sustained free IGF-1R activation without the IGFBP buffering system that modulates native IGF-1 activity in healthy physiology