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One possible unifying model is that direct membrane transfer predominates in short-range spread, whereas redox trigger waves and extracellular relay mechanisms govern propagation over medium to long distances, thereby establishing a hierarchy of spatial coupling mechanisms

EP patent 71,486 Kimura H, Inoe Y, Kobayashi S (1996) Glutathione manufacture with recombinant Saccharomyces

10.1016/j.bbagen.2014.12.001 Biochim Biophys Acta

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We know that caloric restriction and other forms of fasting induce changes in the metabolism of these cells, forcing them to reduce their reliance on glucose and increase the use of mitochondrial oxidative pathways