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Preclinical study in mice with streptozotocin-induced diabetes that showed glucose-independent amelioration of kidney fibrosis with the DPP-4 inhibitor linagliptin
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Effective at lowering HbA1c and may help non-alcoholic fatty liver disease, but causes weight gain, fluid retention (avoid in heart failure), and an increased fracture risk
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Both in vitro and in vivo studies reveal that bisphenol-A exposure during postnatal development alters ER phosphorylation and its translocation to the nucleus in the hippocampus (Xu et al., 2014)
The question is whether the net effect is positive or negative, and the aggregate clinical data strongly suggests it is positive for most people
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