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In particular, the upregulation of IL6, IL1, and Stat3, along with alterations in immune cell populations such as MDSCs and regulatory T cells, and inflammasome suggest plausible mechanistic links to BC pathogenesis 137

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Most people notice changes in their own appearance by weeks 6-8, but friends and family typically comment unprompted around months 3-4

Her disproportionate subcutaneous tissue persisted despite losing weight to reach a nadir BMI of 15 kg/m

For those taking anti-obesity medications, weight regain after discontinuation remains a major concern

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