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In order to treat metabolic acidosis, severely affected patients are given large amounts of bicarbonate and antioxidants such as vitamin E and vitamin C

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A prespecified analysis of SELECT further suggested reductions in composite HF outcomes among participants with and without prior HF, although these findings were secondary analyses rather than HF-dedicated trial endpoints [17]

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For Rybelsus (oral semaglutide), diarrhea was reported in 7.5-8.5% of patients depending on the dose, compared to 4.1% with placebo