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As insulin resistance progresses, the pancreas may compensate by producing more insulin to try to lower blood glucose levels

In contrast, individuals with dyslipidaemia or hepatic steatosis might benefit more from treatment with a glucagon/T 3 conjugate where reductions in hepatic fat and circulating lipids are of primary importance

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If these medications are co-prescribed, thyroid function should be monitored, and patients should discuss with their healthcare provider about appropriate timing of each medication

The bar is higher than it was in 2023

1.0 to 1.7 mg semaglutide weekly