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Chemical Makeup Molecular Formula: C 212 H 350 N 56 O 78 S Molecular Weight: 4963 g/mol Other Known Titles: Thymosin Beta 4 Research and Clinical Studies TB-500 Peptide and Inflammation T4, and thus TB-500, is thought to potentially increase the levels of microRNA-146a (miR-146a), which might function as a suppressive regulator of specific cellular signaling pathways, particularly those associated with the functions of inflammation-related cytokines, including L-1 receptor-linked kinase 1 (IRAK1) and tumor necrosis factor receptor-associated factor 6 (TRAF6)

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This interaction is mediated by dual binding, with FHD mainly binding to the p53 TAD and FOXO4 CR3 binding to the p53 DNA-binding domain (DBD) 38 (Figure